Burkitt’s Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma - Fastest Growing Cancer!!
Hematological malignancies are subdivided into leukemias, lymphomas, and multiple myeloma.
Lymphoma can be Hodgkin or Non-Hodgin's (such as Burkitt's).
Burkitt's is associated with HIV/ AIDS as well as EBV virus.
It has an African subtype (jaw mass) and an American subtype (GI symptoms)...Burkitt's is the most rapidly progressive human tumor.
To diagnose, you need a core needle biopsy or an excisional biopsy of the lymph node (Starry-Sky appearance). Immunohistochemistry for CD19 + , CD20+, CD22+
Uric acid levels can be high---Give allopurinol (Xanthine oxidase inhibitor).
Staging of cancer is important (Ann-Arbor classification).
Treatment: Combination Chemotherapy (R-CHOP) regimen.
Tumor lysis syndrome can ensue.
PET scan is helpful.
The lymph node is a bean-shaped body (not a gland) that interrupts the flow of lymph through the lymphatic vessels.
Afferent lymphatics go towards the lymph node, while efferent exits the node. The lymph node has cortex (which contains the follicle, germinal center, mantle, and margin).
Lymphocyte activation and differentiation occur in the lymph node.
Lymph is a colorless fluid that floats in the lymphatic vessels (lymphatics) of your lymphatic systems.
Formed from the interstitial fluid (extracellular fluid) and returns back to the big veins (Superior vena cava) through the thoracic duct and Right lymphatic duct.
Lymph slows down when it passes in lymph nodes.
Lacteals are a special type of lymph, they are milky because they contain chylomicrons.
Lymph node enlargement can happen in cases of lymphoma (painless lymphadenopathy) or infection (painful).
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