Dr Sophie Postel-Vinay speaks to ecancer about the PIPSeN trial. Initially, she explains the background of this trial. PIPSeN is a randomised, double-blind phase II study that evaluated the PARPi olaparib as maintenance treatment in patients with platinum-sensitive advanced NSCLC. Dr Postel-Vinay then discusses the methodology and key results of this trial. PIPSeN was terminated early with only 50% of the pre-planned patient population available for analysis, thus being statistically underpowered. She concludes that although well-tolerated, olaparib maintenance did not improve median PFS nor median OS in this sample of patients with platinum-sensitive NSCLC.
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