The Battle of Preveza was a naval battle that took place on 28 September 1538 near Preveza in northwestern Greece between an Ottoman fleet and that of a Christian alliance assembled by Pope Paul III in which the Ottoman fleet defeated the allies. It was one of the three largest sea battles that took place in the sixteenth century Mediterranean.

Heyreddin Barbarossa's fleet that summer numbered 122 galleys and galliots. That of the Holy League comprised 300 galleys and galleons (55 Venetian galleys, 61 Genoese/Papal, 10 sent by the Knights Hospitaller and 50 by Spanish ). Andrea Doria, the Genoese admiral in the service of Emperor Charles V was in overall command

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