In this video we compare an experimentally determined SARS-CoV Envelope protein structure (PDB ID: 5X29) with SARS-CoV-2 Envelope (E) protein homology models built with SWISS-MODEL [ Ссылка ]
and MODELLER
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We also explore the homology model’s pore and take advantage of Nanome’s molecular docking plugin, powered by AutoDock Smina, to dock amiloride and hexamethyl amiloride (HMA), which are two inhibitors shown to block this ion channel.

Nanome is the leader in collaborative structure-based design through virtual reality. Explore the nanoscale like never before and experience a more intuitive way to interact with small molecules and/or protein structures through the latest in visualization technology. Nanome enables global real-time collaboration and we’re working closely with some of the top pharmaceutical research facilities and academic research institutions.

Nanome is compatible with the HTC Vive and Oculus Rift. Get started today by downloading Nanome for free on:

Oculus:
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SteamVR:
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Viveport
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Be sure to also check out our blockchain platform, Matryx, which will serve as the backend IP tracking mechanism for Nanome. More info at [ Ссылка ]

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