Various concepts such as phases of Cell Cycle, Retinoblastoma protein, and oncogenes are discussed in the sqadia.com lecture of Pathogenesis of Cancer – I. Now in this, V-Learning™ lecture of Pathogenesis of Cancer – II, discussion continues on its proliferation, cellular senescence, and angiogenesis. Subsequently, invasion and tumor cell motility as well as micrometastasis is considered.

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Lecture Duration: 01:25:02
Released: October 2019

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In this lecture, ligand and their receptors such tyrosine kinase (RTK), G-Protein Coupled Receptors Signalling Pathways, and extracellular matrix receptors are discussed in the very beginning. After that, the action of Ras, MAPKs, and phospholipase C in signaling after receptor activation is highlighted. This lecture is also made easy by talking about the tumor independent functions and tumor dependent functions of transforming growth factor-beta.

Discussion continues on the role of steroid Hormones in Cancer development. The transcriptional activation of Fos and Jun genes leads to the proliferation, invasion and metastasis, and Vasculogenesis and Angiogenesis. Information delivered about cellular senescence include DNA damage response, tumor suppressors, oxidative stress (ROS), and Cytokines like IL-6, IL-8. This is followed by telomere stability and Tumourigenesis.

Then telomere shortening comes under consideration which causes Cell Death and hence act as tumor suppressor. Likewise, oncogene-induced cellular senescence is discussed. Moreover, Apoptosis: Programmed Cell Death is conversed about. In addition to this, light is shed on mediators of tumor angiogenesis, a process in whichBlood Vessels and Blood Cell Formationtakes place. Alongside, Cancer cell ecosystem and tumor cell arrest are comprehensively explained.
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sqadia.com V-learning™ provides you pathology lectures by Doctors and expert clinical pathologists. Aim is to make modern medical student learning easy and provide video medical lectures according to standard syllabus of MBBS and other medical sciences. Standard and Reference books of pathology are followed e.g. “Rubin's Pathology - Clinicopathologic Foundations of Medicine” by David S. Strayer.
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