Tycel Phillips, MD, City of Hope, Duarte, CA, discusses the role of venetoclax in relapsed/refractory (R/R) mantle cell lymphoma (MCL) and highlights treatment options for patients who progress after venetoclax treatment. Dr Phillips explains that venetoclax is currently being explored in combination with ibrutinib in the second-line setting. For patients who progress on this agent in third line and beyond, CAR-T therapy with brexucabtagene autoleucel (brexu-cel) is a promising option. Dr Phillips also comments on the role of pirtobrutinib in this setting. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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