Presented By: Gurpreet Balrey, PhD
Speaker Biography: Dr. Gurpreet Balrey is the Head of Business for Europe, Middle East and Africa for the Genome Engineering and Modulation franchise at Merck. He attended the University of Nottingham for a Biotechnology degree followed by a PhD in Molecular Biology and Plant Genetic Engineering at the same University. Gurpreet has held various positions within the technical sales team during his 11 years with the company. He has particularly been involved in working with the Welcome Trust Sanger Institute to bring the arrayed whole genome libraries to market and more currently on our SygRNA® synthetic two part and single guide CRISPR RNA offering.
Webinar: Advances in CRISPR Screens: Gene Modulation and Single-Cell Analysis Provide New Insights
Webinar Abstract: Multi-target screening can offer great insight into the genetic pathways in drug resistance and disease. RNAi and the fast pace of CRISPR technology development has brought sophisticated options for library screens including the possibility of genome-wide, epigenetic target gene modulation. CRISPRi allows for targeted suppression of gene function while CRISPRa offers a gain-of-function approach to screening. Both complement existing loss-of-function and gain-of-function technologies such as RNAi and ORFs; and have several distinct advantages, including efficient targeting of non-coding genes. You can also take your screens to the single-cell level by using our 10X Genomics compatible CRISPR guide vectors containing capture sequences that allow efficient feature barcoding of individual cells for transcriptomics across pools of guides, allowing functional genomic analysis of top screen hits for single-cell genomic exploration.
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