Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, Prostaglandin,Leukotrienes - Physiology, Pharmacology, Biochemistry
Arachidonic Acid (Ara. A) is one of the major inflammatory mediators in your body...It's liberated from the plasma membrane phospholipid by the phospholipase A2 enzyme. By cyclooxygenase (COX), arachidonic acid can be converted into prostaglandins (e.g. thromboxane A2, prostacyclin "Prostaglandin I2 or PGI2", PGE2, PGF2-alpha, and others.
By 5-lipooxygenase enzyme (LOX), the arachidonic acid can be converted into leukotrienes (e.g. LTB4, LTC4, LTD4, LTE4) which act as chemotactic agent "to recruit neutrophils for inflammation" and bronchoconstrictors "bad for asthma patients.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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