The secret to defying the relentless march of age-related damage could be closer than we think, concealed within the very building blocks of life. The DREAM protein complex is like a cellular command center that governs the way our cells manage DNA damage, which has a direct impact on aging and the development of age-related diseases.

A study published in Nature Structural and Molecular Biology shows that inhibiting the DREAM complex, enhances the DNA repair capacity of somatic cells in worms, mice, and human cells. DREAM represses DNA repair genes in somatic cells, and by inhibiting the DREAM complex, the cells became more resistant to ionizing radiation and the effects of cancer drugs like cisplatin.

While the models used in this research may not perfectly replicate human aging, the findings offer valuable insights into the potential of reversing age-related damage accumulation by manipulating certain genes in certain tissues.

SOURCES AND FURTHER READING
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
Inhibiting DREAM for Enhanced DNA Damage Repair - [ Ссылка ]

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - [ Ссылка ]

LIKE WHAT WE DO?
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
If you’d like to help us run this show and/or help Lifespan.io end age-related diseases, you can become a Lifespan Hero: [ Ссылка ]. Your support means the world to us!

FOLLOW US EVERYWHERE
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
Website: [ Ссылка ]
Instagram: [ Ссылка ]
Facebook: [ Ссылка ]
Twitter: [ Ссылка ]
Discord: [ Ссылка ]

FOOTAGE, IMAGES, AND MUSIC CREDITS
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
Music: "Elastic Vibe" by Ziv Moran

PRODUCTION CREDITS
⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺
Host - Emmett Short
Producer & Editor - Ryan O’Shea
Written by - Larisa Sheloukhova, Emmett Short
Art - Mattijs Vonk, Tim Maupin
Executive Producer - Keith Comito

#DNA #DREAM #Protein #Longevity

The opinions of the hosts and subjects of this video do not necessarily reflect the view of lifespan.io.

свернуть