Next Generation Biophysics Symposium 2023 - Talk 8
Technological advances in MS-based proteomics: deep visual and single cell proteomics for precision medicine
Speaker: Matthias Mann, Max-Planck Institute of Biochemistry, Germany
Chair: Maria Flocco, AstraZeneca, UK
Co-Chair: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK

Matthias Mann describes how recent advances in mass spectrometry have allowed more comprehensive investigations of global proteomics and construction of protein interaction networks. He explained how his recent work on developing new technology and data analysis aims to make proteomics biologically and clinically relevant. He detailed new methods for single cells proteomics overcoming the challenges of low sample volumes by increasing the sensitivity and reproducibility. This has been combined with new machine learning image analysis coupled with laser microdissection to allow cell-type specific proteome analysis from tissue samples. Matthias gives examples of applications to understand the proteomic changes leading to disease states revealing new targets for treatments and the temporal changes during cancer development. In addition, he shows how these techniques can be applied to normal tissue and organoid development to characterise spatial and cell-specific proteomes.

Read more about Matthias Mann’s work here:
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