Altogen Biosystems [ Ссылка ] provides the Liver Targeted Transfection Invivo Kit [ Ссылка ]. Efficient in vivo liver-targeted delivery of nucleic acids and proteins is enabled with the Altogen® Biosystems.

This product falls into the category of the versatile in vivo transfection kits that Altogen® Biosystems offers. Degradation of cargo molecules is minimized and delivery efficiency is maximized for any negatively charged molecules (DNA, RNA).

-Summary:
Modes of administration:
Systemic intravenous (i.v.) injection
Direct intratumoral (i.t.) injection
Intraperitoneal (i.p.) injection
Liver-targeted In Vivo Transfection Reagent
Biodegradable lipid liposome-based reagent
Liposome conjugated complexes are stable in serum (16h)
Efficient delivery to the liver tissue (via systemic administration) and liver tumors (via intratumoral administration)
Efficient siRNA, shRNA, microRNA, and plasmid DNA delivery
Minimal toxicity
Functionally validated in mice
Applicable for plasmid DNA/siRNA co-injection

-Systemic administration generally translates to clinical research better than localized administration, as diseases can require intravenous or intraperitoneal injections, while local administration can be beneficial over systematic in some cases as it requires lower doses and therefore produces lower side effects.

Altogen Biosystems tissue-targeted in vivo transfection kits also require less siRNA or DNA sample than other commercially available transfection reagents.
-The general process is simple: mix, dilute, vortex and inject!

The hands-on time is less than 30 minutes

With the Altogen Biosystems kidney targeted Kit, less of the delivery cargo is required to achieve maximum mRNA knockdown

-Product Details:
Our kits are easy to use and effective: Mix, dilute, vortex, and inject!
Our kits allow for sustained mRNA knockdown after a single siRNA injection
Target liver through different administration routes.
There is very low in vivo toxicity and it is safe to use as there is no detectable inflammatory response (ELISA).
Used for preclinical research worldwide!

-Systemic administration (i.v.) of Liver In Vivo Transfection Reagent conjugated with 80 ug of chemically modified siRNA targeting Lamin A/C mRNA or non-silencing control siRNA following the recommended protocol.
-Intratumoral administration (i.t.) of Liver In Vivo Transfection Reagent conjugated with 80 ug of chemically modified siRNA targeting Lamin A/C mRNA or non-silencing control siRNA following the recommended protocol.
-Systemic administration (i.v.) of Liver In Vivo Transfection Reagent conjugated with 80 ug of chemically modified siRNA targeting Lamin A/C mRNA or non-silencing control siRNA following the recommended protocol.

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