Jason Westin, MD, FACP, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the role of ibrutinib in the treatment of diffuse large B-cell lymphoma (DLBCL), and further highlights the Smart Start study (NCT02636322), which is evaluating the efficacy of ibrutinib in combination with lenalidomide and rituximab in patients with DLBCL. Dr Westin also comments on the growing importance of next-generation Bruton's tyrosine kinase (BTK) inhibitors, and where these may fit in the treatment landscape of DLBCL. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.

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