(13 Jan 2022) The air conditioners hum constantly in the lab at the Wellcome Sanger Institute, countering the heat thrown off by rows of high-tech sequencing machines that work seven days a week analyzing the genetic material of COVID-19 cases from throughout the UK.
The laboratory is one example of how British scientists have industrialized the process of genomic sequencing during the pandemic, cutting the time and cost needed to generate a unique genetic fingerprint for each coronavirus case analyzed.
That made the UK a world leader in COVID-19 sequencing, helping public health authorities track the spread of new variants, develop vaccines and decide when to impose lockdowns.
But now researchers at the Sanger Institute in Cambridge and labs around the UK have a new mission: sharing what they've learned with other scientists.
The omicron variant now fueling a new wave of infection around the world shows the need for global cooperation, said Ewan Harrison, a senior research fellow at Sanger.
Omicron was first identified by scientists in southern Africa who quickly published their findings, giving public health authorities around the world time to prepare.
Since dangerous mutations of the virus can occur anywhere, scientists must monitor its development everywhere to protect everyone, Harrison said, drawing a parallel to the need to speed up vaccinations in the developing world.
"We need to be prepared globally,'' he said. "We can't just kind of put a fence around an individual country or parts of the world, because that's just not going to cut it.''
Britain made sequencing a priority early in the pandemic after Cambridge University Professor Sharon Peacock identified the key role it could play in combating the virus and won government funding for a national network of scientists, laboratories and testing centers known as the COVID-19 Genomics UK Consortium.
This allowed the UK to mobilize academic and scientific expertise built up since British researchers first identified the chemical structure of DNA in 1953.
The consortium is now backing efforts to bolster global sequencing efforts with a training program focused on researchers in developing countries.
With funding from the UK government, the consortium and Wellcome Connecting Science plan to offer online courses in sampling, data sharing and working with public health agencies to help researchers build national sampling programs.
"There is inequity in access to sequencing worldwide, and (the project) is committed to contributing toward efforts that close this gap,″ the group said, announcing plans to offer the first courses early this year.
By sequencing as many positive cases as possible, researchers hope to identify variants of concern as quickly as possible, then track their spread to provide early warnings for health officials.
The UK has supplied more COVID-19 sequences to the global clearinghouse than any country other than the US and has sequenced a bigger percentage of its cases than any large nation worldwide.
Researchers in the UK have submitted 1.68 million sequences, covering 11.7% of reported cases, according to data compiled by GISAID, which promotes rapid sharing of information about COVID-19 and the flu.
The US has supplied 2.22 million sequences, or 3.8% of its reported cases.
Most countries are doing some sequencing but the volume and speed varies greatly.
While 205 jurisdictions have shared sequences with GSAID, more than half have sequenced and shared less than 1% of their total cases.
At Wellcome Sanger's state-of-the-art lab, samples arrive constantly from around the country.
Find out more about AP Archive: [ Ссылка ]
Twitter: [ Ссылка ]
Facebook: [ Ссылка ]
Instagram: [ Ссылка ]
You can license this story through AP Archive: [ Ссылка ]
