Francine Foss, MD, Yale University School of Medicine, New Haven, CT, provides an overview of the current treatment landscape of T-cell lymphomas. Phosphoinositide 3-kinase (PI3K) inhibitors such as duvelisib and tenalisib, which can be combined with romidepsin, as well as Janus kinase (JAK) inhibitors including seralutinib represent promising therapeutic options for patients with T-cell lymphomas. Tipifarnib, a farnesyltransferase inhibitor, as well as selinexor are additional drugs that are potential treatments and Prof. Foss additionally highlights novel combinations such as azacitidine and romidepsin, or azacitidine and CHOP. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.

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