In late August of 1999, an infectious disease specialist in Queens, New York reports that she has two elderly patients with neurological disorders. More cases crop up in the following days, several patients die. Initial tests confirm that New York has been hit by an outbreak of the mosquito-borne illness, St. Louis encephalitis.

Nearly a month later, exotic birds begin to die at the Bronx Zoo. Zoo officials discover they have been infected with West Nile, a virus never before diagnosed in the Western Hemisphere. With this new information, epidemiologists studying the cases of St. Louis encephalitis are lead to a different and shocking conclusion, the virus is spreading to humans.

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