Mucosal Melanoma - Histopathology, Head and Neck Pathology

- Pleomorphic spindled and/or epithelioid cells infiltrating in sheets or loosely cohesive nests and cords
- Melanin pigment is often present
- An in situ component in the overlying mucosa may be observed
- Immunoprofile Description
Positive
S100 (nuclear and cytoplasmic)
S0X10 (nuclear)
Melan A (cytoplasmic)
HMB45 (cytoplasmic)
Negative
Cytokeratins (location)

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