Current treatment options for metastatic pancreatic cancer in the first-line setting include gemcitabine with nab-paclitaxel, FOLFIRINOX, or NALIRIFOX. Benedikt Westphalen, MD, PhD, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany, discusses the trial design of the Phase II FOOTPATH trial (NCT03487016) of deescalated FOLFIRINOX to FOLFIRI, based on the NAPOLI regimen, versus a sequential FOLFIRINOX regimen in patients with metastatic pancreatic cancer (mPDAC). This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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