Title: Intranasal Drug Delivery to the Brain
Objective: We aim to present the relevant preclinical and clinical literature related to intranasal targeting of biotherapeutics to the CNS and speculate on future directions.
Novelty/Scientific importance/Commercial applicability: Drug delivery into the central nervous system (CNS) compartment is often restricted by the blood–brain barrier (BBB) and blood–cerebrospinal fluid barriers (BCSFB) that separate the blood from brain interstitial and cerebrospinal fluids, respectively. BBB is typically impermeable to polar pharmaceuticals and large biotherapeutics intended for CNS treatment. Intranasal administration is a noninvasive method of drug delivery that potentially allows even large biotherapeutics access to the CNS along extracellular pathways associated with the olfactory and trigeminal nerves. Rapid effects, ease of self-administration, and the potential for frequent, chronic dosing are among the potential advantages of the intranasal route.
Methodology: The whole concept will be depicted as a model using basic stationary. The entire concept will be divided into five parts (a) Background of the project, (b) Underlying mechanisms, (c) Diagrams/figures wherever applicable, (d) Pharmacological/commercial relevance, (e) Conclusion and future prospects.
Name of the Students:
1. Pallavi Priya
2. Manish Kumar Meena
3. Anil Kumar
4. Usman Abdulahi Aliyu
5. Aryan Thapa
Name of the supervisor: Mr. Venkata Krishna Rao Balaga
