Measurement of Feline Bladder Pressure and Volume Using Catheter-Free Wireless Intravesical Sensor

Majerus S1, Deng K2, Hanzlicek B1, Panda B2, Mrowca J2, Bourbeau D1, Damaser M2

1. Louis Stokes Cleveland VA Medical Center, 2. Cleveland Clinic Lerner Research Institute

KEYWORDS: Animal Study, New Devices, Physiology, Urodynamics Techniques, New Instrumentation

Lower urinary tract neurophysiology research relies on animal models (e.g. feline) with implanted nerve recording and stimulating electrodes. These systems enable conscious recording of peripheral nerve data, e.g. from the dorsal root ganglia [1], but there are few options for simultaneous measurements of bladder function. In research animal models, catheterization for cystometry requires anesthesia which affects neuro-urological pathways, or animal restraint, limiting measurement time and social behaviors surrounding natural bladder filling and micturition. To overcome this limitation, we developed a catheter-free, wireless, intravesical sensor that is implanted into the bladder lumen of felines and is designed to transmit untethered bladder pressure and volume data in the absence of a wire crossing the detrusor tethering the bladder [2]. This research tool is expected to enable studies in physiologically-relevant settings, and would allow long-term monitoring of lower urinary tract changes in reaction to neuromodulation or pharmacologic interventions. This study validated sensor function and physiologic outcomes over 4-week implantations, including untethered catheter-free wireless recordings of bladder pressure during natural bladder filling and voiding in felines.

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