Listen as Judy Van de Water, Ph.D. describe recent research using machine learning to identify several patterns of maternal autoantibodies highly associated with the diagnosis and severity of autism.
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Dr. Van de Water joined the faculty in the Department of Internal Medicine at the University of California, Davis in 1999. In 2000, she also joined the faculty of the newly formed UC Davis M.I.N.D. Institute when she began her research on the immunobiology of autism. Dr. Van de Water’s laboratory pursues research programs pertaining to autoimmune and clinical immune-based disorders including the biological aspects of autism spectrum disorders. The application of Dr. Van de Water’s immunopathology background has been instrumental in the dissection of the immune anomalies noted in some individuals with autism, and in the differentiation of various autism behavioral phenotypes at a biological level. Most notable of these is the investigation of the maternal immune system as it relates to autism spectrum disorders, with particular emphasis on the presence of highly specific maternal autoantibodies to fetal brain proteins. Dr. Van de Water’s seminal work in this area has led to a highly specific biomarker of autism risk as well as three patents leading to the commercialization of this technology. Dr. Van de Water is currently the Director of the NIEHS funded Center for Children’s Environmental Health at UC Davis, investigating potential environmental risk factors contributing to the incidence and severity of childhood autism.
00:00 - Intro
1:05 - New way of looking at autism
2:55 - Goals of autism research
4:17 - Maternal Autoantibody Related Autism (MAR-ASD)
6:35 - Initial studies and findings
9:29 - MAR target proteins
13:24 - ADOS and SCQ
15:05 - Modifiable risk factors
16:03 - Pathogenic autoantibodies
17:05 - Passive transfer models
19:35 - Rhesus Monkeys - atypical social development and brain volume
20:57 - Maternal autoantibody model
21:00 - MAR antibodies localize in the brain
23:38 - MAR antibodies taken up into developing neurons
26:03 - Golgi strain of mature neurons
27:25 - Development of rodent model
31:32 - Clarity imaging of MAR-ASD offspring
33:43 - Video: decreased sociability in juvenile MAR-ASD mice
36:10 - Voice prints of MAR-ASD male mice
37:40 - Development of preclinical rat model
40:25 - Video: rat behavior
42:00 - Commonalities across models
42:35 - Conclusions
45:05 - Q&A
