22.3.2018 - Čarobnost DNK, molekule življenja in njenih struktur | The magic of DNA, the molecule of life and its structures
prof. dr. Janez Plavec
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Deoksiribonukleinsko kislino, DNK, poznamo po nizu nukleotidov, ki nosi genetska navodila, uporabljena pri rasti, razvoju, delovanju in razmnoževanju vseh znanih živih organizmov in veliko virusov. Najbolj znana struktura molekule DNK je sestavljena iz dveh pramenov, ki se medsebojno prepletata in tako tvorita dvojno vijačnico. V telomernih zaporedjih in v promotorskih regijah se pojavljajo z gvanini bogata območja, ki so pomebna v procesih staranja in regulacije izražanja. Te lastnosti zaporedij in njihove funkcije so povezane s strukturami sestavljenimi iz štirih pramenov, ki jih imenujemo G-kvadrupleksi. Jedrska magnetna resonanca, NMR, omogoča študije povezav med molekularno strukturo DNK in njenimi biološkimi aktivnostmi ali načinom delovanja. Sodelavci NMR centra na KI smo določili in v mednarodni periodiki predstavili nove kvadrupleksne strukture z gvanini bogatih fragmentov DNK in s tem prispevali k razumevanju njihove vloge pri razvoju živčnega sistema in nevroloških motenj, abnormalno rastjo kosti in hrustanca, razvojem raka in regulacijo osnovnih celičnih procesov.
Deoxyribonucleic acid, DNA, is known by a series of nucleotides that carry genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. The most well-known structure of the DNA molecule consists of two strands that interact with one another forming a double helix. Telomeric sequences and promotion regions exhibit guanine-rich regions, which are important in the processes of aging and regulation of gene expression. These sequence properties and their functions are associated with structures consisting of four strands known as G-quadruplex. Nuclear magnetic resonance, NMR, enables studies of correlations between molecular structure of DNA and its biological activities or mode of action. NMR center at NIC has determined and published in international journals new quadruplex structures adopted by guanine-rich regions of DNA fragments thus contributing to understanding of their roles in neurodevelopment and neurological disorders, abnormalities in bone and cartilage development, cancer as well as basic cellular processes.
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