A new study shows that humans express a powerful hormone during exercise and that treating mice with the hormone improves physical performance, capacity and fitness. Researchers say the findings present new possibilities for addressing age-related physical decline.
“Mitochondria are known as the cell’s energy source, but they are also hubs that coordinate and fine-tune metabolism by actively communicating to the rest of the body,” said Changhan David Lee, assistant professor at the USC Leonard Davis School of Gerontology and corresponding author of the study. “As we age, that communication network seems to break down, but our study suggests you can restore that network or rejuvenate an older mouse so it is as fit as a younger one.”
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About the study:
“MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis” ([ Ссылка ]) first appeared online on Jan. 20, 2021. The study’s first author is USC Leonard Davis postdoctoral researcher Joseph C. Reynolds. Co-authors include Rochelle W. Lai, Ryan Lu, Pinchas Cohen and Bérénice A. Benayoun of the USC Leonard Davis School; Jonathan S.T. Woodhead, Cameron J. Mitchell, Troy L. Merry and David Cameron-Smith of the University of Auckland, New Zealand; and James H. Joly and Nicholas A. Graham of the USC Mork Family Department of Chemical Engineering and Materials Science. Cohen is a co-founder, stockholder and board member of CohBar Inc., which is based in Menlo Park, Calif., and conducts research and development of mitochondria-based therapeutics. Lee is a consultant for and a stockholder of CohBar. CohBar is in clinical trials with a MOTS-c analogue.
#PhysicalDecline #MuscleHomeostasis
