Conférence de Vincent COLOT intitulée Demystifying transgenerational epigenetics
00:00:00 Introduction
00:00:54 “Classical” mutations are not always to be found in the DNA sequence
00:06:46 Questions
00:08:24 Arabidopsis provides an ideal system to explore epigenetic variation
00:09:43 A complex machinery ensures the maintenance of DNA methylation
00:10:49 ddm1-derived epigenetic Recombinant Inbred Lines (epiRILs)
00:13:52 ddm1-induced DMRs show variable transgenerational stability
00:14:54 ddm1-induced DMRs match those present in nature
00:17:53 Do stable ddm1-induced DMRs cause heritable phenotypic variation?
00:18:18 EpiRILs display heritable variation for flowering time
00:18:44 QTL mapping
00:18:59 QTL profiles
00:19:38 Parental epi-haplotypes can be used to detect sporadic reversion
00:20:34 Sporadic reversion
00:20:51 Exploring environmentally-induced epigenetic variation
00:21:56 A final note of caution
00:23:31 Acknowledgements
00:23:52 Take home messages
00:24:11 Questions
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