In multiple sclerosis, the rate of brain atrophy (shrinkage) is accelerated compared to normal aging. How fast is the rate of atrophy? Can disease modifying therapies stop it? What about HSCT?
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Selected Sources:
Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options: [ Ссылка ]
Cortical atrophy is relevant in multiple sclerosis at clinical onset: [ Ссылка ]
Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study: [ Ссылка ]
The effect of disease-modifying therapies on brain atrophy in patients with clinically isolated syndrome: a systematic review and meta-analysis: [ Ссылка ]
MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice: [ Ссылка ]
Table 1 Brain atrophy outcomes in pivotal trials of approved disease-modifying drugs: [ Ссылка ]
Five years of ocrelizumab in relapsing multiple sclerosis OPERA studies open-label extension: [ Ссылка ]
Reduced brain atrophy rates are associated with lower risk of disability progression in patients with relapsing multiple sclerosis treated with cladribine tablets: [ Ссылка ]
Early brain pseudoatrophy while on natalizumab therapy is due to white matter volume changes: [ Ссылка ]
Impact of autologous haematopoietic stem cell transplantation on disability and brain atrophy in secondary progressive multiple sclerosis: [ Ссылка ]
Intermediate-Intensity Autologous Hematopoietic Stem Cell Transplantation Reduces Serum Neurofilament Light Chains and Brain Atrophy in Aggressive Multiple Sclerosis: [ Ссылка ]
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
