Since the late 1960s, gel electrophoresis has been the standard of care for the detection of monoclonal proteins. Mayo Clinic’s high throughput clinical electrophoresis laboratory has stagnated in tests per full-time employee (FTE) as manual, semi-batch runs and paper result tracking are limiting our gel-based detection of monoclonal immunoglobulins (M-proteins). We recently described a MALDI-TOF mass spectrometry method (MASS-FIX) as a plausible replacement for gel-based immunofixation (IFE). However, to use MASS-FIX, a fully validated, automated method meeting current analytical capabilities was required. This webinar will cover the development work, clinical applications, analytical validation, and implementation of a MASS-FIX within the Mayo Clinic Protein Immunology Laboratory.

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