Francesco Maura, MD discusses a study presented that uses whole genome sequencing to predict patient outcomes after anti-BCMA CAR-T therapy for multiple myeloma. The research highlights how specific genomic alterations can influence therapy response, suggesting a more personalized approach to treatment and the potential for targeting other therapies for patients with genomic instability.
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ASH Abstract: Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma
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