Desi the 1 year old kitty had a fever 🌡️ weakness & inappetence for 1 month ! Symptoms & tests revealed FIP so we started injectable 💉 GS-4415234 therapy.
FIP develops when feline enteric coronavirus (FECV), a common benign intestinal virus, mutates into the malignant FIPV virus. Discovered by a Cornell veterinarian in 1963, this mutant moves from intestinal cells to white blood cells called macrophages. Traveling through the body, it killed most cats within weeks. Kittens are particularly vulnerable, especially in shelters.
GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir & GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
Unlike published substances or drugs that inhibit FIPV by hampering cellular processes usurped by viruses for their replication,13,14 small molecules like GS-441524 interfere directly with replicative processes encoded by the virus 🦠
Many thanks go out to people involved in this case from @visionvetimaging for the help with a diagnostic ultrasound to @fip_warriors_5.0 who help us vets manage FIP & to @kraftie2008 for supplying us with our 1st vial of GS #fipwarriorsofinstagram #fipsurvivor #felineinfectiousperitonitis #catsofinstagram❤️ #kıttensofinstagram #fipcatsupport #veterinaryultrasound #veterinaryradiology #kittyfever #fipcatsofinstagram #fipcats
