#progesteronevspessary #pregnancycomplication #pretermbirth
Progesterone provides protection to infants against preterm birth: Study
According to a study published in the Journal The BMJ, cervical pessary may be less effective than vaginal progesterone in reducing adverse perinatal outcomes in women with a singleton pregnancy with no prior spontaneous preterm birth of less than 34 weeks’ gestation and with a cervical length of 25 mm or less. Preterm birth is the most important problem in obstetric care and globally the most important cause of neonatal mortality, morbidity, and subsequent neurodevelopmental disorders. Progesterone is widely understood to reduce preterm birth in pregnant women with a short cervical length. A second potential preventive treatment is the use of a cervical pessary, which was reported to reduce preterm birth at less than 34 weeks in women with a singleton baby and a cervical length of less than 25 mm. The Amsterdam UMC research team studied the optimal treatment for pregnant women with a cervical length shorter than 25 mm at the 20-week ultrasound. Eligible participants had a healthy singleton pregnancy and a cervical length of 35 mm or less between 18 and 22 weeks gestation. Those assigned to the pessary group received an Arabin25 cervical pessary, removed at 36 weeks. Participants in the progesterone group self-administered 200 mg vaginal progesterone capsules daily until 36 weeks. Data collection included maternal and obstetric history, pregnancy details, and neonatal outcomes, with follow-up until 10 weeks after the due date. The results revealed that in women who had singleton births with no prior spontaneous preterm birth of less than 34 weeks’ gestation and with a mid-trimester cervical length of 35 mm or less, pessary did not improve perinatal outcome compared with progesterone. In the subgroup of a cervical length of 25 mm or less, differences seemed larger in favour of progesterone, especially for extremely preterm birth at less than 28 weeks. "This is an important improvement that can contribute to the reduction of preterm births and the associated complications, such as an increased risk of infant mortality and long-term health problems for the child," said Eva Pajkrt, professor of obstetrics at Amsterdam UMC. "Based on our study, we recommend measuring the length of the cervix of all pregnant women during the 20-week ultrasound. Women with a cervix shorter than 25 mm should be informed about the possibility of treatment with Progesterone."
Check full updates on Medical Dialogues
Also check out -
Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism.
🔗 Enroll Today: [ Ссылка ]
📚 Explore More With Us:
📌 Medical Content Writing: [ Ссылка ]
📌 Certificate Course in Pharmaceutical Medico-Marketing: [ Ссылка ]
Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting.
Get the latest medical and health news at medicaldialogues.in
Follow us on
Twitter: [ Ссылка ]
Facebook: [ Ссылка ]
Instagram: [ Ссылка ]
LinkedIn: [ Ссылка ]
Website: [ Ссылка ]
