This video focuses on the serotonin receptors and their molecular biology, pharmacology, and psychological effects when stimulated.
Serotonin (also known as 5-hydroxytryptamine or 5-HT) is a neurotransmitter molecule used in a huge variety of neurobiological processes. There are 14 different 5-HT receptors in the brain and body, each with a fairly unique intracellular signaling mechanism and distinct psychological effects.
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This is the first in a miniseries on the neurobiology of the serotonin system. Link to the rest of the serotonin videos: [ Ссылка ]
Chapters:
00:00 Serotonin (5-HT) is NOT just the happiness molecule
00:35 The goals and approach of this video and miniseries on serotonin
01:36 This is a new style for Sense of Mind’s neuroscience videos
02:18 Part 1: Mechanism of serotonin synaptic transmission
03:05 How SSRIs work
03:28 The “need-to-know” of synaptic transmission
03:57 Serotonin is a “neuromodulator” that can work extra synaptically
04:44 Part 2: Families and subtypes of 5-HT receptors
05:20 Most 5-HT receptors are GPCRs
06:00 5-HT1 and 5 receptor inhibitory mechanisms
06:30 5-HT2, 4, 6, and 7 receptors excitatory mechanisms
07:02 5-HT3 receptor excitatory mechanism
07:33 Please sign up for the video newsletter and podcast!
08:16 Part 3: What do the different receptors do to the brain?
09:28 Some effects of stimulating 5-HT receptors in the human brain
10:28 Resolving some paradoxes of 5-HT pharmacology (presynaptic receptors and biased agonism)
12:25 Examples of bodily effects of 5-HT stimulation
13:10 How can one neurotransmitter do so much?
13:59 Conclusion: Some remaining questions
14:35 - Please like and subscribe! Thank you!
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Sources Cited:
1. Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. [ Ссылка ]
2. Di Giovanni, G., & De Deurwaerdère, P. (2020). Serotonin research: Crossing scales and boundaries. [ Ссылка ]
3. Hoyer, D. (2020). Targeting the 5-HT system: Potential side effects. Neuropharmacology, 108233. [ Ссылка ]
4. Mosienko, V., Bader, M., & Alenina, N. (2020). The serotonin-free brain: behavioral consequences of Tph2 deficiency in animal models. In Handbook of Behavioral Neuroscience (Vol. 31, pp. 601-607). Elsevier.
5. Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120. [ Ссылка ]
6. Bacqué-Cazenave, J., Bharatiya, R., Barrière, G., Delbecque, J. P., Bouguiyoud, N., Di Giovanni, G., ... & De Deurwaerdère, P. (2020). Serotonin in animal cognition and behavior. International journal of molecular sciences, 21(5), 1649. [ Ссылка ]
7. Carvajal-Oliveros, A., & Campusano, J. M. (2021). Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?. Frontiers in Behavioral Neuroscience, 14, 262. [ Ссылка ]
8. Dingman M. Know Your Brain: Raphe Nuclei. Neuroscientifically Challenged. [ Ссылка ]. Published October 27, 2017.
9. JJ Medicine. “Serotonin and Melatonin Synthesis | Tryptophan Metabolism” [ Ссылка ].
