Video transcript :-

Gabapentin is a medication that was originally developed as an anticonvulsant.
Structurally, it is a derivative of the neurotransmitter gamma-aminobutyric acid, or GABA, but it does not bind to GABA receptors.
Instead, it is used for a variety of neurological and neuropathic pain conditions.
Major indications of gabapentin include the following.
For the treatment of epilepsy.
To control neuropathic pain especially in conditions such as post-herpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia.
And for the treatment of restless legs syndrome.
Off label uses of gabapentin include treatment of anxiety disorders, hot flashes, migraine, and fibromyalgia.
Gabapentin's exact mechanism of action is not fully understood, but it is believed to work by Binding to the alpha 2 delta subunit of voltage-gated calcium channels in the central nervous system.
This action reduces the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P, thereby modulating synaptic transmission.
It does not act directly on GABA receptors, nor does it influence GABA synthesis or uptake, despite its structural resemblance to GABA.
Gabapentin is available as oral tablets, oral capsules, and oral solutions.
Gabapentin is absorbed from the gastrointestinal tract, and its bioavailability decreases with increasing doses.
The immediate-release form has a bioavailability of approximately 60% at lower doses.
Gabapentin is not significantly metabolized and is excreted unchanged in the urine.
Common adverse effects of gabapentin include the following.
Drowsiness.
Dizziness.
Fatigue.
Ataxia.
Peripheral edema.
Weight gain.
Nausea and vomiting.
And Blurred vision.
In some cases, more serious side effects like mood swings, depression, or suicidal thoughts may occur.
Contraindications of gabapentin include, Hypersensitivity, and severe renal impairment.

#gabapentin #neuropathicpain #pharmacology #medtoday #medicaleducation #medicalknowledge #drugs #medications #healtheducation #healthyliving

herpes zoster,ria health,how to take gabapentin,neuropathic pain,gabapentin 300 mg,gabapentin mechanism of action,jj medicine,gabapentin side effects,gabapentin side effects and why they occur,gabapentin,gabapentin fatigue,gabapentin most common side effects,gabapentin adverse effects,gabapentin uses,gabapentin treatment,gabapentin drowsiness,gabapentin somnolence,gabapentin dizziness,gabapentin weight gain,gabapentin constipation,neurontin,gralise

свернуть