The CANDELA trial (NCT04126317) was a phase II, randomized, single-masked, open-label, clinical trial that assessed the safety and efficacy of aflibercept 8 mg versus the standard dose of 2 mg in patients with neovascular age-related macular degeneration (nAMD). It was a pleasure to speak with Dr Jordana Fein (Retina Group of Washington Fairfax, VA, USA) around the results of the CANDELA study and the clinical impact of the findings.

The presentation entitled ‘Additional visual and anatomic outcomes of intravitreal aflibercept injection 8 mg versus 2 mg: a post hoc analysis of the Phase 2 CANDELA study’ was presented at the Association for Research in Vision and Ophthalmology Annual Meeting, May 05-09, 2023

Questions:

What is the rationale for using aflibercept 8 mg compared with aflibercept 2 mg in the treatment of nAMD? (0:20)
What were the primary and secondary endpoints and how well were they achieved? (1:39)
What will be the likely clinical impact of these findings? (4:40)
Disclosures: Jordana Fein has nothing to disclose in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Shanice Allen.

Filmed in coverage of the virtual ARVO 2023.

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