The problem:
LNP researchers spend tons of time screening, optimizing, then scaling up experiments to get optimal performance, spot-on targeting and controlled API release. Factors like solubility, pH stability, payload release, encapsulation, and more all hinge on particle size, shape, and structure. That means exploring a huge number of formulation and process parameters one-by-one to get it right. Once you’ve found the perfect formulation, scaling up typically means switching instruments and re-optimizing your settings all over again, with single use consumables racking up costs along the way.
The solution:
Meet the Sunny Suite. Sunscreen is the only automated and high-throughput screening platform for LNP formulation. Run up to 96 experiments in under 6 hours to power through your LNP formulation discovery phase. When you’ve identified your winners, walk right over to Sunshine for protocol development, process optimization, and rapid scale-up. Sunshine can run up to 10 experiments in just 15 minutes – letting you fine-tune size and design the perfect process in a jiff. When you’re ready to scale-up, switch the instrument to Continuous Mode and make tens of liters per day. Sunny Suite platforms use the exact same methods and reusable Sunnies so handover between platforms is totally seamless.
The proof:
Watch our webinar to see first-hand data results demonstrating the power and flexibility of our Sunny Suite platforms for high-throughput formulation screening through process optimization and pre-clinical scale-up. We will demonstrate how you can significantly accelerate your screening stage by performing up to 96 experiments in under 6 hours - testing combos of individual lipids, payloads, flow rates, ratios and sample sizes to your heart’s content. We’ll also show you how easy it is to optimize your process, switching out flow rates and ratios, then scale-up to continuous flow on the same instrument.
