In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
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Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: [ Ссылка ]
Effects of MDMA on sociability and neural response to social threat and social reward: [ Ссылка ]
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity: [ Ссылка ]
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: [ Ссылка ]
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: [ Ссылка ]
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): [ Ссылка ]
Science forced to retract article on “ecstasy”: [ Ссылка ]
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: [ Ссылка ]
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: [ Ссылка ]
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: [ Ссылка ]
Books
PIHKAL: A Chemical Love Story: [ Ссылка ]
Trauma: The Invisible Epidemic: [ Ссылка ]
The Body Keeps the Score: [ Ссылка ]
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): [ Ссылка ]
Participate in a MAPS trial: [ Ссылка ]
Huberman Lab episode on psilocybin: [ Ссылка ]
Huberman Lab episode on psychedelics for mental health: [ Ссылка ]
Huberman Lab episode on dopamine, mindset & drive: [ Ссылка ]
Huberman Lab episode on leveraging dopamine: [ Ссылка ]
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - [ Ссылка ]
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