GLP-1 Receptor Agonists: antidiabetic and weight loss management drugs: A Complete Review
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0:00 Introduction to GLP-1 Receptor Agonists
- Overview of GLP-1 Analogs in Diabetes Treatment and Weight Management
1:30 Types of GLP-1 Receptor Agonists
- Dulaglutide (Trulicity®), Liraglutide (Victoza®, Saxenda®), Semaglutide (Ozempic®, Wegovy®, Rybelsus®)
3:15 Dosage and Administration
- Daily vs. Weekly Dosing of GLP-1 RAs
5:00 Mechanism of Action
- How GLP-1 Analogs Mimic Endogenous Incretin for Glucose Regulation
7:00 Clinical Use of GLP-1 Agonists
- Glycemic Control, Weight Loss, Cardiovascular Benefits
9:45 Cardiovascular Trials
- GLP-1 RAs and Cardiovascular Disease Risk Reduction
11:30 Storage Conditions for GLP-1 Agonists
- Proper Storage Guidelines for GLP-1 RAs
12:30 Warnings and Precautions
- Thyroid C-Cell Tumors, Pancreatitis Risks
14:00 Contraindications
- Personal or Family History of Medullary Thyroid Cancer, MEN2
15:00 Common Side Effects
- Gastrointestinal Symptoms and Risk of Hypoglycemia
16:45 Drug-Drug Interactions
- Minimal Interactions Observed in Clinical Trials
17:45 Use in Pregnancy and Breastfeeding
- Not Recommended Due to Potential Risks
19:00 Monitoring and Follow-Up
- Regular Monitoring of Blood Glucose, HbA1c, Renal Function
20:30 Pharmacokinetics
- Absorption, Metabolism, and Excretion of GLP-1 Analogs
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