Bradley A. McGregor, MD, Dana Farber Cancer Institute, Boston, MA, highlights the implications of the double antibody-drug conjugate (DAD) Phase I trial (NCT04724018), which assessed the safety and efficacy of sacituzumab govitecan combined with enfortumab vedotin in the treatment of metastatic urothelial carcinoma (mUC). The trial indicated that antibody-drug conjugates with different payloads and toxicities may be combined safely which may lead to novel treatment approaches in different diseases. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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