Oncology for Students: Why are antiandrogens given with LHRH agonists in Prostate Cancer?

Oncology for Students: Prostate cancer: LHRH agonists (such as leuprolide) used in the treatment of prostate cancer are known to cause a "flare" through a transient increase in testosterone. LHRH agonists should be started with an antiandrogen (such as bicalutamide) to help prevent this from occurring.

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