This lecture starts by explaining what GABAergic neurons in the spinal cord do to alpha motor neurons. It then introduces the role of synaptobrevin and how the tetanus toxin interferes with it causing muscle spasms. Next it explains what SNAP-25 is and how the botulinum toxin interferes with it causing muscle paralysis. It finishes by explaining what the drug Botox is.
0:00 GABAergic Neurons and Alpha Motor Neurons
9:25 Synaptobrevin
11:00 Tetanus Toxin, Synaptobrevin, and Muscle Spasms
14:11 Botulinum Toxin and SNAP-25
17:11 Muscle Paralysis
20:36 Botox
