Presented By: Leah Schmidt, PhD
Speaker Biography: Leah Schmidt, PhD, is a postdoctoral fellow in the laboratory of Dr. Philip Greenberg at the Fred Hutchinson Cancer Research Center, and an AACR-AstraZeneca Immuno-oncology Research Fellow. Her research is focused on utilizing preclinical models for refining and improving engineered T cell therapies against solid tumors, including lung and pancreatic cancers. Prior to Fred Hutch, Dr. Schmidt completed her PhD thesis in the laboratory of Dr. Tyler Jacks at the Massachusetts Institute of Technology, where she studied the roles of natural killer cells in shaping anti-tumor immune responses in genetically engineered preclinical models. Her overarching scientific interest is uncovering strategies for improving patient outcomes by leveraging the immune system against human disease.
Webinar: Using genetically engineered preclinical models to study T cell therapy against solid tumors
Webinar Abstract: Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~50% of patients. Adoptive cellular therapy (ACT) with T cells engineered to express T cell receptors (TCRs) specific for tumor-associated antigens (TAAs; proteins overexpressed by cancers) is an approach that circumvents the need for endogenous T cell responses. TCR-ACT is effective against hematologic cancers, but ACT against solid tumors is in the early stages of exploration. A deeper understanding of complex interactions between therapeutic cells and the tumor microenvironment (TME) is crucial for identifying successful strategies to enhance function and mitigate toxicity.
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