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UFC Fight Night: Bisping vs. Gastelum (also known as UFC Fight Night 122) was a mixed martial arts event produced by the Ultimate Fighting Championship and held on November 25, 2017, at Mercedes Benz Arena in Shanghai, China.

A middleweight bout between former UFC Middleweight Champion Anderson Silva and The Ultimate Fighter: Team Jones vs. Team Sonnen middleweight winner Kelvin Gastelum was expected to serve as the main event. The pairing was previously scheduled to meet in June 2017 at UFC 212. However, Gastelum was pulled from the bout after he tested positive for Carboxy-Tetrahydrocannabinol (Carboxy-THC) which is a metabolite of marijuana or hashish above the 180 ng/mL allowance by the World Anti-Doping Agency (WADA) standard. In turn, despite having two months to secure an opponent, Silva and promotion officials confirmed on May 11 that he would not compete at that event.

On November 10, it was announced that Silva had failed an out of competition drug test stemming from a sample collected on October 26 and as a result had been pulled from the card. A day later, former UFC Middleweight Champion and The Ultimate Fighter 3 light heavyweight winner Michael Bisping was secured as a replacement opponent for Gastelum. Bisping had fought 21 days prior to this event at UFC 217, where he lost the championship to former two-time UFC Welterweight Champion Georges St-Pierre.

Gastelum defeated Bisping by knockout in the first round. He also earned his second Performance of the Night bonus award.

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