This video addresses the therapeutic potential of curcumin, a substance found in turmeric, to prevent Alzheimer’s disease. The information presented in this video has integrated research including in vitro studies that aimed to observe the influence of curcumin based interventions in the neuropathology of Alzheimer’s disease. From mechanisms for neurogenesis to the disintegration of beta amyloid plaques, this video highlights that there are many pathways by which curcumin can elicit its effects. However, there are currently not enough human trials to support the mouse-model studies for turmeric’s ability to prevent Alzheimer’s.

Music thanks to: bensound.com

Video by Chantal Gillett, Shalini Namathirtham, Tanya Kakkar, Harris Joseph and Kahiye Warsame

Please let us know how you liked this video and suggest additional topics for us to demystify.

Copyright McMaster University 2016

References

1. Akram, M., Uddin, S., Ahmed, A., Usmanghani, K., Hannan, A., Mohiuddin, E., & Asif, M. (2010). Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol, 55(2), 65-70.

2. Baum, L., Lam, C., Cheung, S., Kwok, T., Lui, V., & Tsoh, J. et al. (2008). Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease. Journal Of Clinical Psychopharmacology, 28(1), 110-113. [ Ссылка ]

3. Bodkin, H. (2016, May 20). Retrieved from [ Ссылка ]

4. Kim, J. O. (2015) Toothpaste composition containing Curcuma longa l. and method of manufacturing same. U.S. Patent Application No. 15/102,197.

5. Mishra, S., & Palanivelu, K. (2008). The effect of curcumin (turmeric) on Alzheimer′s disease: An overview. Annals of Indian Academy of Neurology, 11(1), 13. doi:10.4103/0972-2327.40220

6. Samantaa, A. K., & Agarwal, P. (2009). Application of natural dyes on textiles. Indian Journal of Fibre & Textile Research, 34, 384-399.

7. Shankaracharya, N. B., & Natarajan, C. P. (1973). Turmeric-chemistry, technology and uses. Indian Spices, 10(3), 7-11.

Tiwari. K. S., et al. (2013). Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-Catenin pathway. American chemical Society. DOI: 10.1021/nn405077y. Retrieved October 19, 2016.

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