Duncan Gilbert, MA, MRCP, FRCR, PhD, University College London, London, UK, discusses the Phase III PATCH trial (ISRCTN70406718), which investigated transdermal estradiol as an alternative to traditional androgen suppression (LH-RH analogues) in men with locally advanced, treatment-naive prostate cancer. Patients from the STAMPEDE trial (ISRCTN78818544) were additionally recruited and results from the locally advanced cohort were presented. Patients were randomized between standard LH-RH therapy and the experimental use of transdermal estradiol patches. This interview took place at the European Society for Medical Oncology (ESMO) 2024 Congress in Barcelona, Spain.
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