Why children are less sensitive to acute acetaminophen intoxication than adults?

Jaeschke, H., Akakpo, J. Y., Umbaugh, D. S., & Ramachandran, A. (2020). Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure. Toxicological Sciences, 174(2), 159-167.
Caparrotta, T. M., Antoine, D. J., & Dear, J. W. (2018). Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. European journal of clinical pharmacology, 74(2), 147-160.
Yan, M., Huo, Y., Yin, S., & Hu, H. (2018). Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox biology, 17, 274-283.
Mladenović, D., Radosavljević, T., Ninković, M., Vučević, D., Ješić-Vukićević, R., & Todorović, V. (2009). Liver antioxidant capacity in the early phase of acute paracetamol-induced liver injury in mice. Food and chemical toxicology, 47(4), 866-870.
Masubuchi, Y., Suda, C., & Horie, T. (2005). Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. Journal of hepatology, 42(1), 110-116.

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