Binjari virus is a flavivirus isolated in Australia from infected mosquitos. The structure of Binjari virus reveals an immature-like organisation, which has remained elusive for global flavivirus pathogens like dengue, yellow fever or Zika virus.
This provides the first complete view of a flavivirus particle before it gains infectivity and represents a new blueprint for the design of better vaccines.
An unexpected organisation of the projecting spikes is incompatible with previous models of maturation. This video first zooms in on critical features of the immature particle before describing the guided collapse that is key to the transition to infectious particles.
(Video courtesy of A/Prof Coulibaly and Dr Joshua Hardy)
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