This is me capturing the legendary Genetic Pokémon, Mewtwo, during my Pokémon FireRed walkthrough.

The legendary Pokémon are extremely hard to catch, even if on low health and under a status condition, so bring along as many Ultra Balls as you can, and also have some Great Balls for possible backup. My recommendation is that you DO NOT use your Master Ball on this thing, for there is STILL a Pokémon that is EVEN harder to catch on the loose in the game.

Mewtwo can be VERY annoying, as its stats are through the roof, it knows Safeguard to protect itself from status conditions, Recover to regain lost HP, Psychic to do some really nasty STAB damage, and Swift as an attack that never misses. A good way to start would be to put a non-damaging status ailment on Mewtwo before it can use Safeguard, most preferably paralysis, as it doesn't wear off. After that, start widdling down Mewtwo's health, until you are at the red zone. After this, start throwing Poké Balls at Mewtwo. Ultra Balls are OK, but what I REALLY recommend is that you go to Two Island and buy a bunch of Timer Balls before doing this, since while the battle progresses, Timer Balls become more and more effective and useful every turn, even surpassing Ultra Balls from certain point onwards.

Mewtwo can be found at the bottom floor of the Cerulean Cave, which is located near Cerulean City. Due to the cave containing very high-level Pokémon, a Cooltrainer will stand at the its entrance, preventing you from entering it until you've defeated the Elite Four and the Champion and entered the Hall of Fame at least once.

PS. I know this video contains a lot of re-loads, but I just couldn't bring myself of starting the whole thing over and over again. The last time I tried to catch Mewtwo, I tried to catch it dozens of times, but as it didn't go anywhere, despite of the many close calls, I got frustrated and finally said, "Screw it!" and caught it with my Master Ball. This became even more annoying later on, as I was supposed to catch Suicune without the Master Ball. And boy, I can tell you it was a Hell to go through! I apologize for this, and wish that you understand me.
PPS. Once again, sorry for the audio and visual going off-sync.
PPPS. Please comment and rate! :D

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