Presented By:
Javad Parvizi MD
Dr. James Snyder
Speaker Biography:
Dr. Parvizi is a board certified orthopaedic surgeon and has been at the Rothman Institute since 2003. He specializes in the management of young patients with hip disorders such as dysplasia and femoroacetabular impingement. He has performed over 1000 femoroacetabular osteoplasty procedures, 300 pelvic and femoral osteotomies, and over 5000 hip replacements in young adults and continues to lead the clinical research team at the Rothman Orthopaedic Institute. Dr. Parvizi is a native of Azerbaijan, Iran and lived there until the age of 16. He completed his medical school education in the United Kingdom. Following graduation from medical school he spent four years in surgical training that included cardiothoracic surgery. Dr. Parvizi then traveled to the United States to spend two years at the Mayo Clinic to conduct research in identifying methods to regenerate cartilage and bone. After obtaining a Masters degree in molecular biology from the Mayo Clinic, Dr. Parvizi was offered a residency in orthopedic surgery at the Mayo Clinic. He completed his residency in orthopedic surgery at the Mayo Clinic and traveled to Switzerland to do a fellowship in the management of hip disorders in young adults. He spent time with Professor Ganz at the Inselspital, Berne in 2002. After completion of his fellowship, he joined the Rothman Orthopaedic Institute. His personal area of interest in research and clinical practice includes prevention and diagnosis of joint infection, joint preservation in adults, and prevention of thromboembolism following orthopedic procedures.
Dr. Snyder is currently the Director of Microbiology and Infectious Disease Molecular Diagnostics at the University of Louisville Hospital, Louisville, KY. He holds the academic title of Professor in the Department of Pathology and Laboratory Medicine. He is board certified in Medical Microbiology and Public Health by the American Academy of Microbiology and was elected to Fellowship in the Academy in 1989.
Prior to joining the University of Louisville School of Medicine, Dr. Snyder served as the Director of Microbiology at the Norton-Kosair Children’s Hospital (1977-1986) and the Veteran’s Administration Medical Center in Louisville (1973-1977).
Webinar:
The Expanding Role of Next-Generation DNA Sequencing (NGS) in PJI Diagnosis and Clinical Microbiology - Part II
Webinar Abstract:
Timely and accurate detection of an infective organism(s) impacts the treatment course and potentially patient outcomes. Although traditional culture has served as the “gold standard” for the recovery and isolation of potential pathogens, NGS, a culture independent genomic technology, has become attractive to undertake coincidently for the genotypic detection of potential pathogens. The limitations inherent in traditional microbiological culture techniques—including how biofilm, viable but non-culturable bacteria, and persister cells hinder diagnosis and treatment of these infections—were discussed in detail in Part 1 of this webinar series. Watch On-Demand
NGS has played an important role in the detection of potential microbial pathogens in patients with periprosthetic joint infection (PJI), when infection exists in the form a biofilm and traditional culture fails to isolate the etiological agent in up to 50% of cases. Recent studies have shown that NGS can determine the type of pathogen(s) causing PJI in 90% of the cases when culture was negative. Further, studies have shown that NGS is also extremely useful in urosepsis, neurological infections, and many other fields.
NGS provides more comprehensive information about the presence of microbial population, results are usually available in 24 hours in most cases and is cost effective. There is ample evidence to support the use of NGS in management of patients with infection.
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