Hox genes are the blueprints to pattern most animals, and they critical to making sure the body plan and patterning is laid down. There is something unique about mammalian Hox genes in particular. They are very close together in the DNA strand. They are tight! Here I explore a paper exploring why this happens and how it could be used to regulate mammal bodies.
This is the first video in a series of research articles on Hox genes and how they are being studied by scientists currently.
This video is a description and commentary for the following article:
The constrained architecture of mammalian Hox gene clusters
Fabrice Darbellay, Célia Bochaton, Lucille Lopez-Delisle, Bénédicte Mascrez, Patrick Tschopp, Saskia Delpretti, Jozsef Zakany, Denis Duboule
Proceedings of the National Academy of Sciences Jul 2019, 116 (27) 13424-13433; [ Ссылка ]
This paper is published under a Creative Commons License (CC BY-NC-ND)
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If you have any questions, please post them in the comments. I will make a follow-up to video to answer the most pressing questions, so please check that out if you're interested in learning more.
This is about a research article and the focus is on learning about current research on Hox genes. While you will learn a lot about Hox genes, this is not meant to be a full explanation of them. Here are some fantastic educational videos that focus on explaining Hox genes:
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Special thanks to Gabriel G. Martins and Tomas pais de azevedo for the use of the chick embryo development video
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More places I am:
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Information for the images used in the video:
"Framed Embroidery Kidney Anatomy Art. Hand Embroidered." by Hey Paul Studios is licensed under CC BY 2.0
"Chicago (ILL) Chicago Transit Authority, CTA, W. Van Buren St. ' Lasalle / Van Buren station (140/400S)' 1897" by (vincent desjardins) is licensed under CC BY 2.0
"Grand Theft Auto IV" by Silvio Sousa Cabral is licensed under CC BY 2.0
"Cat With Gun" by roosac is licensed under CC BY 2.0
"Possum" by Jay Phagan is licensed under CC BY 2.0
"Fruit fly" by John Tann is licensed under CC BY 2.0
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