We found that synaptic transmission in inhibitory interneurons is modulated by DNA methylation-dependent regulation of endocytosis-related genes. As changes in neuronal activity can lead to alterations in DNA methylation profiles, this could serve as a subcellular mechanism for neuronal metaplasticity.
Analysis of human brain sample analysis further points to a potential implication of DNA methylation-dependent endocytosis regulation in the pathophysiology of temporal lobe epilepsy, a disease characterised by disturbed synaptic transmission.
