The long-term use of hormonal blockade in prostate cancer treatment poses significant risks that warrant careful consideration. While androgen deprivation therapy (ADT), which includes hormonal treatments like GnRH agonists or antagonists, effectively suppresses testosterone production to slow cancer growth, it can lead to a range of adverse effects over time. These may include osteoporosis and bone fractures due to decreased bone density, cardiovascular complications such as increased risk of heart disease and stroke, metabolic changes like weight gain and insulin resistance, and potential cognitive impairment. Furthermore, the psychological impact of hormonal therapy, including mood changes and decreased libido, can significantly impact a patient's quality of life. Regular monitoring and proactive management of these risks through lifestyle modifications, bone health interventions, cardiovascular monitoring, and psychological support are crucial to minimizing complications and maintaining overall well-being in patients undergoing long-term hormonal blockade for prostate cancer. *The expert's opinions in this communication are personal and not representative of any organization. They are for informational purposes only, not official guidance. Viewers are advised to use their judgment, seek additional advice, and take responsibility for any actions based on these opinions. #prostatecancer

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