A decline in NAD+ during aging is believed to be a major cause of disease and disability, such as hearing and vision loss, as well as cognitive and motor dysfunction, immune deficiencies, auto-immunity, and dysregulation of the inflammatory response leading to arthritis, metabolic dysfunction, and cardiovascular disease. In mouse models, NAD+ boosters prevent or treat a variety of different diseases, prompting a search for NAD+ boosters that are safe and effective as drugs to treat both rare and common diseases, and potentially aging itself.

More on the Evolutionary aspect of NAD since i got cut off:
Much has been written about modern maladaptations relative to our long hunter-gatherer days. These mismatches usually concentrate on loss of fibre or excessive sugar or fructose or gluten in recent affluent diets.5,11–23 We argue that a high risk of too little nicotinamide may be the most important difference between diets in the past 10 000 years and those in the Palaeolithic. During that long time, as we (co)evolved much of our nutrigenome, microbiome, and ‘meat cultures’, variances were usually ‘feasts or famines’ (or fatal as meat then provided most of the calories) rather than chronic shortages over lifetimes. The first Neolithic agricultural revolution and the second ‘Green revolution’ 50 years ago may have, as an unintended consequence, reduced meat and micronutrients for those in poverty. Both revolutions increased cereal availability reducing hunger but not the ‘hidden hunger’ of micronutrient deficiency in something of a ‘Faustian’ bargain.
From
Journal of Tryptophan Research 2017,
Meat Intake and the Dose of Vitamin B3 – Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?
Lisa J Hill and Adrian C Williams
#NAD #aging #antiaging

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