Epithelial mesothelioma is the most common of the three types of mesothelioma cancer. Approximately 70% of cases are epithelial. Epithelial and epithelioid are used interchangeably to refer to this asbestos-related cancer.

Epithelial mesothelioma cells clump together in groups. Each cell is square or cubic in appearance. The nucleus — the area of the cell that contains genetic material — is clearly visible in each cell.

Because epithelioid cells lack mobility and adhere closely together, they are less likely to spread compared with sarcomatoid cells. This is one of the reasons epithelial mesothelioma has the best prognosis of the different mesothelioma cancers.

Early and Late Mesothelioma Symptoms :
- Shortness of breath
- Persistent, nonproductive (dry) cough
- Hoarseness
- Coughing up blood
- Low blood oxygen levels and anemia (low iron)
- Weight loss
- Feeling full, even without eating
- Lack of appetite and nausea
- Fatigue and weakness

Treatments for epithelioid mesothelioma include:
- Surgery: Surgery is a mainstay of epithelial mesothelioma treatment, although some patients may not be eligible for it due to other health conditions.
- Chemotherapy: The standard, FDA-approved chemotherapy for treating epithelioid mesothelioma is a combination of Alimta (pemetrexed) plus cisplatin or carboplatin.
- Radiation therapy: Radiation therapy may be used alone or in combination with surgery and chemotherapy. Radiation is not curative for mesothelioma, but it can help manage symptoms and lessen pain.
- Multimodal: According to The Annals of Thoracic Surgery 2019 paper, multimodal therapy, a combination of two or more therapies, resulted in significantly better outcomes for patients with epithelial malignant pleural mesothelioma.

There are key steps you can take to find the best mesothelioma treatment to meet your needs. Patients who seek out specialty mesothelioma care and receive all of the treatments for which they are eligible have the best life expectancy.
* See an Expert.
A study published April 2019 in The Annals of Thoracic Surgery, suggests many mesothelioma patients do not receive treatment consistent with national guidelines. This is less likely to happen if you go to a high-volume mesothelioma center where doctors see many patients with this rare disease.
* Consider Alternative Chemotherapy.
If you can’t take the FDA-approved chemotherapy cocktail of Alimta (pemetrexed)and cisplatin, work with your doctor to find another chemotherapy plan to best meet your needs.
* Improve Quality of Life.
Ask if adding radiation therapy to your palliative care plan is a good idea. While this treatment modality won’t cure mesothelioma, it shouldn’t be dismissed out of hand. It can help you feel much better.


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